Statins Suspected To Negatively Impact Omega-3 Fatty Acids Status

Statins

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Research has shown that statins can increase the relative amounts of Arachidonic Acid (AA) in the blood.  So while some statin drugs may weakly lower triglycerides in addition to cholesterol, the drug-induced lowering of serum fatty acid concentration also altered the relative percentages of important omega-3s and other PUFAs.  The results warn of possible increases in the AA:EPA ratio (Harris et al, 2004), a silent pro-inflammatory change marker.

To counter, high DHA/EPA consumption is now highly recommended for individuals at high risk for heart disease, enjoying qualified health claims by the FDA.  Studies suggest increased dietary n-3 fatty acids may result in a more favorable fatty acid profile during statin treatment.  Monitoring of the AA:EPA ratio as an early marker of inflammation could be an important consideration for patients on these side-effect prone cholesterol-lowering drugs.

REFERENCE: Harris JI, Hibbeln JR, Mackey RH, Muldoon MF, Statin treatment alters serum n-3 and n-6 fatty acids in hypercholesterolemic patients. Prostaglandins, Leukotrienes and Essential Fatty Acids Volume 71, Issue 4, October 2004, Pages 263-269.